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10 Best Cystic Acne Spot Treatments - Holiday Sale

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Last Updated - 2025/12/14

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01
VICHY

Vichy Normaderm Anti-Acne Spot Treatment With 10% Sulfur, Glycolic Acid & Niacinamide Vitamin B3. Dries out pimples overnight, prevents acne blemishes. Fragrance-free, Dermatologists-recommended, 20ML

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8.4 Light weight

8.0 worth the money

8.0 Aroma
Main highlights

Vichy Normaderm Anti-Acne Spot Treatment With 10% Sulfur, Glycolic Acid & Niacinamide Vitamin B3.
Suitable for Very Dry, Dry, Normal, Oily, Acne Prone, Combination, Sensitive, and Mature Skin
How to Use: Cleanse skin thoroughly with NORMADERM ANTI-ACNE PURIFYING GEL CLEANSER, Apply acne spot treatment directly onto the pimples at night after application of NORMADERM ANTI-ACNE DOUBLE-ACTION LOTION. Avoid eyes.
Fragrance-free, Dermatologists-recommended
Dries out pimples overnight, prevents acne blemishes.
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9.8

Exceptional

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02
Rael

Rael Miracle Invisible Spot Cover - Absorbing Cover, Hydrocolloid Patch, Korean Skin Care, Facial Stickers, 2 Sizes (96 Count)

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9.7 Simple to take off

9.3 Attachment

9.1 Sheerness
Main highlights

VEGAN AND CRUELTY-FREE - No animal-derived ingredients. No animal testing.
STAYS ON SKIN ALL DAY, NIGHT - Tapered edges adhere to skin.
NOTE - The Lot number on the back of the packaging defines the Manufacturing Date, not the Expiration date.
INVISIBLE COVERAGE - Clear, matte finish and extra thin outer edge seamlessly blends in with all skin tones.
EFFECTIVE CARE - Made with medical-grade, highly absorbent hydrocolloid. Non-drying and hypoallergenic. Comes in 2 sizes (10mm and 12mm)
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9.5

Excellent

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03
Clean & Clear

Clean & Clear Persa-Gel 5 Oil-Free Acne Spot Treatment with Maximum Strength 5% Benzoyl Peroxide, Topical Pimple & Acne Medication for Face Acne, Fragrance-Free, 28g

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9.1 Simple to use

8.7 worth the money

8.0 Moisturizing
Main highlights

To use, clean the skin and apply a thin layer of spot treatment to affected areas one to three times a day as a part of your daily acne skincare routine.
This maximum strength* acne treatment is formulated free of parabens, phthalates, fragrance, oil and dyes. It features a vegan formula that is not tested on animals and is packaged in a recyclable carton. *Highest non-prescription strength available Suitable for acne-prone or oily skin, fragrance free Persa-Gel 5 helps clear acne and kills acne-causing bacteria.
The benzoyl peroxide spot treatment for acne penetrates deep down into pores where acne begins.
Fragrance free acne spot treatment contains 5% benzoyl peroxide acne medication that goes to work immediately to help fight pimples and blemishes.
28-gram tube of Clean & Clear Persa-Gel 5 Oil-Free Acne Spot Treatment with Maximum Strength* 5% Benzoyl Peroxide acne medication to help effectively treat pimples and kills acne causing bacteria.*Highest non-prescription strength available
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9.4

Excellent

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04
Neutrogena

Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 5% Benzoyl Peroxide Acne Treatment Medication for Acne Prone Skin Care, 28g

11% Off Free Shipping

9.3 Simple to use

8.7 worth the money

8.4 Aroma
Main highlights

Use maximum strength gel as part of your acne-clearing skincare products routine up to 3x per day
Spot treatment for acne-prone skin helps clear up even your most stubborn acne breakouts
One 28-gram tube of Neutrogena Rapid Clear Maximum Strength Acne Spot Treatment Gel, Stubborn Acne
Gel contains 5% benzoyl peroxide, the non-prescription acne medicine dermatologists recommend most
Clinically proven to rapidly reduce the size & redness of stubborn acne pimples in just two hours
Clears up breakouts you have now while also helping to prevent future ones from forming
Acne-fighting gel actively fights breakouts for continuous improvement in skin's appearance
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9.2

Excellent

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Value for Money

05
OXY

Oxy Deep Pore Acne Vanishing Treatment - 5% Benzoyl Peroxide – Stubborn Acne Control - Helps Treat, and Prevent Breakouts – Allows Skin to Heal - Dermatologist Tested

15% Off Free Shipping

8.7 Simple to use

8.0 worth the money

8.0 Aroma
Main highlights

SUITABLE FOR ALL SKIN TYPES: Dermatologist tested, ensuring a safe and effective solution for your acne concerns.
SOOTHING INGREDIENTS: Contains SymCalmin to soothe skin, along with Portulaca Extract to calm and reduce redness.
RAPID PIMPLE TREATMENT: Helps treat acne pimples and accelerates skin healing.
ACNE BACTERIA ELIMINATION: Targets and eliminates acne-causing bacteria for clearer skin.
5% BENZOYL PEROXIDE: Formulated with 5% Benzoyl Peroxide for quick acne blemish healing and prevention.
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9.1

Excellent

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06
Neutrogena

Neutrogena Rapid Clear Acne and Pimple Spot Treatment Gel with Salicylic Acid and Witch Hazel, 15 mL

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Main highlights

Works to clear breakouts fast and helps stop new ones from forming, even before they become visible. For best use, cover the entire affected area with a thin layer of spot treatment one to three times daily after cleansing.
The maximum-strength formula of this acne medicine is designed for acne-prone skin and is clinically proven to reduce pimple size, swelling, and redness in eight hours.
Our pimple spot treatment contains witch hazel, a natural ingredient known for its skin-soothing properties, as well as 2 salicylic acid acne medicine to penetrate pores and clear blemishes.
From the 1 dermatologist-recommended brand, this spot treatment gel features powerful Microclear Technology designed to boost delivery of acne medicine which helps clear congested pores deep at the source.
0.5-fluid ounce tube of Neutrogena Rapid Clear Acne Eliminating Spot Treatment Gel with Witch Hazel made with salicylic acid and witch hazel to visibly reduce breakouts and help prevent acne
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8.9

Very Good

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07
CeraVe

CeraVe Acne Control Gel For Face, Pimple & Pores, With Salicylic Acid, 3 Essential Ceramides, Niacinamides. Developed with Dermatologists, Non-Comedogenic, Oil-Free, Fragrance-Free, 40ml

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Main highlights

Minimizes Pores & Gently Exfoliates: Combines salicylic acid (BHA) and AHA for gentle exfoliation, reducing the appearance of pores
Lightweight & Oil-Free Gel: This non-comedogenic gel absorbs quickly without leaving a greasy residue, making it ideal for daily use
Hydrates & Supports Skin Barrier: Formulated with three essential ceramides, niacinamide, and hyaluronic acid to maintain a healthy skin barrier and prevent dryness
Developed with Dermatologists: Expertly formulated to be gentle yet effective for acne-prone skin
Acne Control Gel Treatment with 2% Salicylic Acid : Developed with dermatologists to help clear acne pimples and minimize the apparence of pores, while maintaining the protective skin barrier
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8.6

Very Good

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08
Clean & Clear

Clean & Clear Advantage Acne Spot Treatment With Salicylic Acid Acne Medication, 22 mL

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9.1 Simple to use

8.2 worth the money

8.0 Moisturizing
Main highlights

Works beautifully under make-up
Water resistant, oil-free and PABA-free
This water-light sunscreen provides UVA/UVB protection with SPF 60
Suitable for use during outdoor activities such as biking or hiking
From a Dermatologist Recommended Brand
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8.5

Good

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09
Thursday Plantation

Thursday Plantation Tea Tree Acne Gel - Spot Solution for Breakout, Whiteheads, Blackheads, Pimples & Blemishes - Gentle for Teens & Adults - 10g

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Main highlights

TARGETED ACNE SOLUTION WITH TEA TREE OIL - Thursday Plantation’s acne gel is formulated with natural tea tree oil to target blemishes, purify pores, and reduce excess oil, helping to clear pimples, whiteheads, and blackheads.
SPOT APPLICATION FOR BLEMISH CONTROL - Lightweight and fast-absorbing, this targeted gel is perfect for direct application on problem areas like the forehead, chin, and cheeks, fitting effortlessly into any skincare routine for ongoing clarity.
GENTLE CARE FOR TEENS & ADULTS - Crafted for teens and adults, this smooth gel provides balanced care, helping manage breakouts without drying the skin. Its easy-to-apply texture integrates seamlessly into any skincare routine.
DAILY USE FOR CONSISTENTLY CLEARER SKIN - Add this gel into your morning and evening routine to help manage pimples, whiteheads, and blackheads. The easy-to-apply formula supports a balanced, refreshed complexion, enhancing your skincare regimen daily.
COMPACT AND PORTABLE TRAVEL SIZE - Packaged in a convenient 10g tube, this acne gel is perfect for on-the-go care. Easily fits into bags or purses for quick spot treatment wherever needed, providing clear-skin support anytime.
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8.3

Good

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10
Neutrogena

Neutrogena Stubborn Acne Blemish Patches, Hydrocolloid Spot Treatment, Pimple Care Patch, Hypoallergenic, 24 Patches Per Pack

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Main highlights

The hypoallergenic, fluid-absorbing patches are perfectly sized to target single pimples and are easy to apply on clean, dry skin. To use, carefully apply the patch over the blemish and leave on for eight hours or overnight.
The hydrocolloid patch adheres to the skin acting as a barrier to the pimple. There are no harsh adhesives used in the pimple patch. The Neutrogena Stubborn Acne Ultra-thin Blemish Patches are hypoallergenic and are non-medicated.
The Neutrogena Stubborn Acne Blemish hydrocolloid patches are from a dermatologist-recommended brand. These pimple patches are easy to use.
Neutrogena's pimple patches remove impurities from skin to help pimples look smaller after just one use. Ideal for acne-prone skin, this hydrocolloid patch is for small facial blemishes and helps protect acne.
Neutrogena Stubborn Acne Ultra-thin Blemish Patches remove impurities from skin to help pimples look smaller and flatter. These ultra-thin acne patches are ideal for treating small facial blemishes. There are 24 pimple patches per package.
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8.0

Good

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